Ipamorelin

Also known as: Ipamorelin acetate

Evidence Tier B-Chigh riskintermediatenot approved

Selective GHSR agonist profiled for more targeted GH release with less ACTH/cortisol spillover than earlier secretagogues.

FDA Safety Flag

The FDA has identified this substance as one that may present significant safety risks when used in compounding, including concerns about immunogenicity, impurity characterization, and/or insufficient safety information.

WADA S2

This substance falls under WADA S2 (Peptide Hormones, Growth Factors, Related Substances and Mimetics). If you are subject to anti-doping rules, this category of substances is prohibited at all times.

GH Axis

This substance modulates the growth hormone axis. GH-axis stimulation carries risks including glucose intolerance, fluid retention, and theoretical concerns about sustained IGF-1 elevation.

Overview

Ipamorelin is a selective growth hormone secretagogue receptor (GHSR/ghrelin receptor) agonist. Originally profiled as more selective with less ACTH/cortisol/prolactin impact than earlier secretagogues, though 'minimal spillover' is dose- and context-dependent. FDA flagged ipamorelin acetate in its compounding safety risk context, citing immunogenicity/impurity characterization concerns including unnatural amino acids.

Research Details

Mechanism of Action

GHSR agonism stimulates GH release; originally profiled as more selective with less ACTH/cortisol/prolactin impact than earlier secretagogues.

Study Dose Range

Human PK/PD: infusion in nmol/kg over ~15 minutes across escalation steps.

Administration Routes

subcutaneous, intravenous

Onset / Timeline

GH pulse effects are acute; body composition claims are long-horizon and not well-established.

Expected Effects

GH-axis biomarker modulation. Body composition effects are speculative in consumer context.

Adverse Effects

Immunogenicity risk (FDA); impurity concerns with unnatural amino acids; glucose/cortisol axis concerns.

Contraindications

No established label contraindications (not approved).

Interaction Notes

High uncertainty; glucose/cortisol axis monitoring concerns consistent with secretagogue class.

Related Goals

Muscle Growth & StrengthFat Loss & MetabolismGH Axis Optimization

Known Interactions

caution with CJC-1295

GHRH analog + GHS-R agonist may produce additive GH release; multiple GH-axis peptides flagged for safety/characterization concerns.

caution with Sermorelin

GHRH analog + GHS-R agonist: additive GH release plausible.

caution with GHRP-6

Multiple GHS/GHS-R stimulation; FDA flags both for compounding risks/limited safety info.

caution with GHRP-2

Multiple GHS/GHS-R stimulation; limited stacking safety evidence.

caution with MK-677

MK-677 and ipamorelin both stimulate ghrelin-pathway signaling; redundancy and endocrine spillover risk rise.

Available From

Amino Club

consumer RUO · COA: product page COA viewer

10 mg / 20 mg (variant-dependent) · variant-dependent on product page

Consumer RUO; review product details carefully

A dedicated Amino Club product page is available for this peptide instead of a generic vendor landing page.

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QC: third-party purity testing; product-level COA on page

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Frequently Compared

CJC-1295

Long-acting GHRH analogue studied in human trials for sustained GH/IGF-1 elevation.

Tier B

Sermorelin

GHRH(1-29) analogue that stimulates pulsatile GH secretion, historically used in clinical settings.

Tier B

Tesamorelin

FDA-approved GHRH analogue for HIV-associated lipodystrophy. Prescription only.

Tier A

GHRP-2

GH secretagogue studied in human stimulation tests with documented endocrine spillover effects.

Tier B

Information provided for educational and research reference only. Not medical advice. Not for diagnosing, treating, curing, or preventing disease. Products referenced are labeled Research Use Only (RUO) by vendors; not for human or veterinary use.