PT-141

Also known as: Bremelanotide, Vyleesi

Evidence Tier Alow riskadvancedrx approved

FDA-approved melanocortin agonist (Vyleesi) for HSDD in premenopausal women. Prescription only.

Prescription Only

This is an FDA-approved prescription product. It should only be obtained through licensed healthcare providers and pharmacies. Do not attempt to source through RUO or gray-market channels.

Overview

PT-141 (bremelanotide), sold as Vyleesi, is an FDA-approved nonselective melanocortin receptor agonist indicated for hypoactive sexual desire disorder (HSDD) in premenopausal women. Administered as 1.75 mg subcutaneous ~45 minutes before anticipated sexual activity. Contraindicated in uncontrolled hypertension or cardiovascular disease. Common AEs include nausea, flushing, injection site reactions, headache, and vomiting. Not indicated for men or postmenopausal women.

Research Details

Mechanism of Action

Nonselective melanocortin receptor agonist (MC1R, MC4R binding); exact mechanism for HSDD improvement unknown.

Study Dose Range

Label: 1.75 mg subcutaneous as needed, ~45 min before anticipated activity. Max frequency limits apply.

Administration Routes

subcutaneous

Onset / Timeline

Designed for acute/as-needed effect within an hour; BP effects peak in hours post-dose.

Expected Effects

Improved sexual desire in premenopausal women with acquired generalized HSDD.

Adverse Effects

Nausea, flushing, injection site reactions, headache, vomiting. BP elevation.

Contraindications

Uncontrolled hypertension, known cardiovascular disease. Avoid co-use with oral naltrexone-containing products.

Interaction Notes

Slowed gastric emptying impacts absorption of concomitant oral meds. Clinically meaningful interaction with oral naltrexone.

Related Goals

Sexual Health & Libido

Known Interactions

contraindicated with Melanotan II

Two melanocortin agonists; FDA reports serious adverse events for melanotan II; Rx bremelanotide has cardiovascular contraindications/warnings.

caution with Melanotan I

Melanocortin agonist overlap; conservative caution.

Available From

Amino Club

consumer RUO · COA: product page COA viewer

10 mg / 20 mg (variant-dependent) · variant-dependent on product page

Consumer RUO; review product details carefully

A dedicated PT-141 product page is available for people who want to review this listing directly.

USVisit Vendor

QC: third-party purity testing; product-level COA on page

Shipping: US/ROW (verify current policy) · affiliate: public program

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Information provided for educational and research reference only. Not medical advice. Not for diagnosing, treating, curing, or preventing disease. Products referenced are labeled Research Use Only (RUO) by vendors; not for human or veterinary use.